Endocrine Abstracts

ObjectiveThe objective of this systematic review was to assess the incidence of growth, new pituitary endocrinopathies, and the incidence of surgery and/or radiotherapy in conservatively treated non-functioning pituitary adenomas/incidentalomas (NFPAs/NFPIs).MethodA bibliographical search of Embase and Pubmed was conducted in order to identify eligible studies.Results<p class="abste...

Objective: Exogenous estradiol increases cortisol binding globulin (CBG) and total cortisol (TC), and therefore it is debated if estradiol supplementation should be paused before evaluation of the adrenal axis. The aim was to evaluate how oral and transdermal estradiol influence TC in hypogonadal women with, or at risk of developing, adrenal insufficiency (AI)Methods: This was a crossover study in 17 women with secondary hypogonadism who were tested with...

Objective: Growth hormone (GH) activity might be implicated in male reproductive function. One previous study has suggested significantly reduced semen quality in untreated acromegalic patients due to both reduced sperm counts and motility.Design and methods: A retrospective study comprising 10 uncontrolled hypogonadal acromegalic patients (median age 29y) who delivered semen for cryopreservation before initiation of testosterone therapy. Semen ...

Introduction: Gonadotropins from the pituitary gland are essential for testosterone production and spermatogenesis. However, little is known about semen quality in patients with adult onset gonadotropin insufficiency.Aim: To investigate semen quality in men with adult onset hypogonadotropic hypogonadism requiring testosterone replacement therapy.Patients and method: A single center study comprising all hypogonadal men with pituitar...

Introduction: A common genetic polymorphism in the GH receptor (GHR) is deletion of the entire exon 3 sequence (GHRd3 isoform). The GHRd3 isoform seems to be more sensitive with increased downstream GH signalling in activated exon 3 deleted receptor dimers (GHRd3/d3) compared to full length receptor dimers (GHRfl/fl). Presence of the GHRd3 isoform might be associated to pre- and postnatal growth and pubertal development in boys, although controversy exists. The aim was to inve...

Background: The growth hormone system (growth hormone, GH and insulin-like-growth-factor I, IGF-I) might be implicated in congestive heart failure (CHF). In experimental models IGF-I increases cardiac contractility and reduces apoptosis of myocytes exposed to ischemic injury. In clinical studies GH-therapy has been used in CHF. One previous population based investigation showed that low levels of IGF-I was associated with an increased incidence of CHF. The result of this inves...

BackgroundSurgical resection is indicated in patients with non-functioning pituitary adenomas (NFPA) causing visual defects or tumor growth in proximity to the optic chiasm. The aim of this study was to systematically assess the benefits and harms of pituitary endocrine function after transsphenoidal surgery in patients with NFPAs.MethodsThis study was conducted a systematic review that searched for potential...

Adrenalectomy for primary aldosteronism has been associated with post-surgical kidney failure. It has been proposed that elimination of excess aldosterone demask an underlying failure of the kidney function. Contralateral suppression (CLS) is considered an indication of aldosterone excess and disease severity and the purpose of this study was to assess the hypothesis that CLS would predict change in kidney function after adrenalectomy in patients with primary aldosteronism. We...

Endocr Connect 2015 vol. 4 no. 1 37–42. DOI: 10.1530/EC-14-0137...

ObjectiveThe objective of this systematic review was to assess the proportion of patients with prolactinomas that obtain remission or experience adverse effects after transsphenoidal surgery.DesignA systematic review. Registered at PROSPERO, registration number CRD42020213002MethodsA bibliographical search of PubMed and Embase was performed and last updated on Sep...